A postdoctoral position in onco-immunology is available at the CRCL in Lyon

We are seeking a highly motivated and scientifically-driven postdoctoral fellow to join our team 'Cancer Immune Surveillance and Therapeutic Targeting'. Our Lab aims to identify new tumor immune surveillance and escape networks to improve cancer treatments. B cells and antibody-producing cells have recently emerged as critical tumor components influencing patient survival and response to therapies, but the underlying mechanisms remain unclear. The current project funded by ANR-RHU and INCa aims to:Decipher the mechanisms underlying plasma cell differentiation in B-cell-hot ovarian tumorsIdentify antigens targeted by dominant expanded clonotypesDetermine the impact of chemo-immunotherapy on B cell diversity and functions in tumor and blood and its association with patient outcomesThe successful candidate will use unique patient samples, including tumors from patients with a paraneoplastic neurological syndrome, internal data sets of bulk and single cell RNA/BCR sequencing, multispectral tissue imaging, flow cytometry, and antibody profiling arrays.Contract: 2 years with possible extension to 3 years.Lab: 'Cancer Immune Surveillance & Therapeutic Targeting' #J-18808-Ljbffr